Generalized Myasthenia Gravis

Advancing Care for Patients with gMG

gMG is a rare, chronic autoimmune neuromuscular disorder that disrupts communication between nerves and muscles, leading to muscle weakness that can impact mobility, vision, swallowing, and breathing. The disease is mediated by autoantibodies, most commonly targeting the acetylcholine receptor (AChR) or muscle-specific kinase (MuSK), which interfere with neuromuscular transmission.

While several therapies are available, many patients continue to experience persistent symptoms or intolerable side effects.

Despite available therapies, many patients continue to experience significant disease burden, and there remains an unmet need for additional treatment option. There are approximately 90,000 people in the United States, 140,000 in Europe, and 29,000 in Japan living with the disease.

Telitacicept is an investigational drug. It has not been approved by the U.S. Food and Drug Administration (FDA). The safety and efficacy of telitacicept have not been established.

Clinical Trials
UPSTREAM MG

Telitacicept in Generalized Myasthenia Gravis (gMG)

The UPSTREAM MG Phase 3 global study is evaluating the efficacy, safety, and tolerability of telitacicept in patients with generalized myasthenia gravis (gMG).

The ongoing Phase 3 global trial is a randomized, double-blind, placebo-controlled study with an open-label extension.

Objective

To assess the impact of telitacicept on MG-ADL and QMG scores in patients with AChR+ or MuSK+ gMG.

Endpoints

Primary – MG-ADL change from baseline at Week 24
Secondary – QMG, MG-QOL15r, responder rates, minimal symptom expression.

Enrollment

~180 patients across North America, Europe, Asia-Pacific.

If you have questions about our Phase 3 study in gMG, please email mgstudy@vorbio.com.

Learn More About Our Clinical Trial In MG (Clinicaltrials.gov)

Resources for People Living with gMG

Myasthenia Gravis Foundation Aspect Ratio 16 9

Myasthenia Gravis Foundation of America

Myasthenia Gravis Foundation of America is a nonprofit patient advocacy organization dedicated to supporting people affected by the rare neuromuscular autoimmune disease myasthenia gravis. They work to improve quality of life through education, support services, community connection, and professional resources, and they fund research aimed at better treatments and, ultimately, a cure for MG.

Myasthenia Gravis Association

Myasthenia Gravis Association is a nonprofit organization focused on supporting people affected by myasthenia gravis (MG)—including patients, their families, and friends—by offering education, resources, and community connection to those impacted by the condition. They aim to increase public awareness, provide essential MG resources and patient education, and foster a supportive community for people living with MG.

MG Holistic Society

MG Holistic Society is a nonprofit organization on a mission to make a difference in the lives of those affected by myasthenia gravis. They are focused on building a future where holistic wellness is accessible to all, transforming challenges into opportunities for growth and healing.

Myasthenia Gravis Foundation Of Michigan

The Myasthenia Gravis Foundation of Michigan (MG-MI) was founded in 1976 to raise awareness about MG and provide resources and support to MG patients and caregivers. Their efforts include support meetings in cities throughout Michigan to provide opportunities for patients, their families, and friends to learn about the illness and share tips on living with the condition.

Conquer Myasthenia Gravis

Conquer Myasthenia Gravis is driven by the desire to help MG patients get prompt diagnosis and optimal care. They are focused on improving the lives of patients with MG through programs of patient services, public awareness, medical research funding, professional education, advocacy, and patient care.

Muscular Dystrophy Association

Muscular Dystrophy Association (MDA) is the #1 voluntary health organization in the United States for people living with muscular dystrophy, ALS, and related neuromuscular diseases. For 75 years, MDA has led the way in accelerating research, advancing care, and advocating for the support of our families. MDA’s mission is to empower the people they serve to live longer, more independent lives.

Caregiver Action Network

Caregiver Action Network (CAN) is the nation’s leading family caregiver organization. They work to improve the quality of life for tens of millions of family caregivers who care for loved ones with chronic conditions, disabilities, or diseases. CAN also supports those meeting the living needs of older adults.

MG Ohio

MG Ohio is committed to supporting those living with myasthenia gravis (MG) and MG-related disorders, as well as their caregivers, friends, family, and the greater MG community by providing information and support through education, community programs, and advocacy, and to raise awareness about MG and MG-related disease.

Myasthenia Gravis Association of Western Pennsylvania

The Myasthenia Gravis Association of Western Pennsylvania (MGA) is a nonprofit organization based in Pittsburgh that supports individuals living with myasthenia gravis. They provide patient education, support services, and resources for patients, families, and healthcare professionals while working to improve quality of life and raise awareness about the condition.