Sjögren’s Disease (SD)

Smiling Mature Woman Standing In A Park Outdoors In The Summertime

A Vastly Underestimated and Underserved Autoimmune Disease

Sjögren’s disease is a chronic autoimmune condition in which overactive B cells drive inflammation, damaging moisture-producing glands and, in many cases, other organs. Hallmark symptoms include dry eyes and dry mouth, alongside fatigue, pain, and systemic complications affecting the skin, lungs, kidneys, and nervous system. About one-third of patients develop significant extraglandular involvement, and the disease carries an elevated lymphoma risk, often leading to substantial impairment in daily life.

One of the most common rheumatic autoimmune diseases, Sjögren’s remains underdiagnosed, with roughly half of cases unrecognized and women comprising the vast majority of patients.

Despite its prevalence and burden, no systemic disease-modifying therapies exist; current care focuses on symptom management with incomplete relief.

 

Resources for People Living with Primary Sjögren’s Disease

Sjogrens Foundation Aspect Ratio 16 9

The Sjogren’s Foundation

A U.S. national nonprofit organization dedicated to supporting people affected by Sjögren’s disease—a chronic autoimmune condition—and their loved ones. It provides education, resources, and services for patients and healthcare professionals, advocates for awareness and patient needs, and encourages and funds research to improve understanding, diagnosis, and treatment of the disease.

Publications Related to Sjögren’s Disease